Trials / NCT06323772
Natural History Study in Patients With PDE6A-, PDE6B- and RHO-linked Retinitis Pigmentosa
Underway, not enrolling Observational Natural history / observational
- Sponsor
- University Hospital Tuebingen
- Treatment
- Not listed
- Gene
- PDE6A, PDE6B, RHO
- Conditions
- Retinitis Pigmentosa
- Ages
- 5 Years to no upper limit
- Enrollment
- 40 participants
- Started
- 2023-11-17
- Main results expected
- 2027-03
- Results posted
- Not yet
- Record last updated
- 2026-05-06
What the study is testing
The aim of the study is to apply a novel clinical investigation protocol in patients with Phosphodiesterase 6A (PDE6A), PDE6B and Rhodopsin (RHO)-based retinitis pigmentosa. This novel, multimodal clinical examination protocol describes and correlates structural, functional and metabolic aspects during natural disease development.
Test-retest variability of new measurements as well as correlations of the structural, functional, and metabolic changes will be defined to be able to define well-suited readouts for safety and efficacy of future treatment developments before they reach the clinical phase.
Where it runs
Germany (1)
- Institute for Ophthalmic Research, University Tübingen, Tübingen, Baden-Wurttemberg