Trials / NCT05914233
Non-invasive Ultrasound Retinal Stimulation for Vision Restoration
Not yet recruiting N/A Device
- Sponsor
- University of Southern California
- Treatment
- Non-invasive ultrasound retinal stimulation Device
- Gene
- Not stated
- Conditions
- Age-Related Macular Degeneration, Retinitis Pigmentosa, Ultrasound Therapy; Complications
- Ages
- 18 Years to no upper limit
- Enrollment
- 5 participants
- Started
- 2027-01-10
- Main results expected
- 2028-01-15
- Results posted
- Not yet
- Record last updated
- 2026-01-08
What the study is testing
This clinical trial aims to test the safety and feasibility of using a non-invasive ultrasound device to stimulate retinal nerve cells and restore vision in patients with age-related macular degeneration. Previous studies have shown that artificial stimulation, such as electric and optic stimulations, can partially restore vision, but these methods are invasive and pose surgical risks. The study aims to develop a non-invasive method for retinal stimulation. The investigators will follow the FDA guidelines to limit the ultrasound power and adhere to all clinical trial regulations to ensure all participants' safety.
The main questions the investigators aim to answer are:
- Is using high-frequency ultrasound safe using a wearable device for localized retinal neural activity stimulation?
- Does the stimulation through the device restore vision in patients with age-related macular degeneration?
Participants in this study will be asked to undergo Optical Coherence Tomography (OCT) scanning before and after the ultrasound stimulation to evaluate the device's safety. Then, they will receive five stimulation-rest cycles and complete a questionnaire to report what they see and how they feel during the device's operation.
Where it runs
No sites listed yet.