Trials / NCT04794101
Follow-up Gene Therapy Trial for the Treatment of X-linked Retinitis Pigmentosa Associated With Variants in the RPGR Gene
Underway, not enrolling Phase 3 Gene therapy
- Sponsor
- MeiraGTx Ocular UK Ltd
- Treatment
- Genetic: AAV5-hRKp.RPGR Intermediate Dose; Genetic: AAV5-hRKp.RPGR Low Dose
- Gene
- RPGR
- Conditions
- X-Linked Retinitis Pigmentosa
- Ages
- 3 Years to no upper limit
- Enrollment
- 97 participants
- Started
- 2020-12-04
- Main results expected
- 2029-09-20
- Results posted
- Not yet
- Record last updated
- 2026-09-25
What the study is testing
A clinical trial of AAV5-hRKp.RPGR vector for participants with X-linked retinitis pigmentosa (XLRP)
Where it runs
Belgium (1)
- Ghent University Hospital, Ghent
Canada (1)
- Hospital For Sick Children, Toronto, Ontario
Denmark (1)
- Rigshospitalet Glostrup, Glostrup Municipality
France (1)
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris
Israel (1)
- Hadassah Medical Center, Jerusalem
Italy (4)
- Azienda Ospedaliero Universitaria Careggi, Florence
- Ospedale San Paolo, Milan
- Azienda Ospedaliera Univ.- Università Degli studi della Campania - Luigi Vanvitelli, Naples
- IRCCS Fondazione G.B. Bietti per lo Studio e la Ricerca in Oftalmologia ONLUS, Rome
Netherlands (2)
- VUMC Amsterdam, Amsterdam
- Radboudumc, Nijmegen
Spain (1)
- Hosp Univ Fund Jimenez Diaz, Madrid
Switzerland (2)
- University Hospital Basel, Eye Clinic/Institute of Molecular and Clinical, Basel
- Universite de Lausanne, Hopital ophtalmique Jules-Gonin, Lausanne
United Kingdom (4)
- NHS Lothian, Edinburgh
- Gartnavel General Hospital, Glasgow
- St James University Hospital, Leeds
- Moorfields Eye Hospital, London
United States (10)
- Shiley Eye Institute Jacobs Retina Center, La Jolla, California
- Childrens Hospital Los Angeles, Los Angeles, California
- Stanford Health Care, Palo Alto, California
- VitreoRetinal Associates, PA, Gainesville, Florida
- Emory University, Atlanta, Georgia
- Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
- Univ of Michigan Medical Center, Ann Arbor, Michigan
- Duke Eye Center, Durham, North Carolina
- University of Pittsburgh Medical Center (UPMC), Pittsburgh, Pennsylvania
- Retina Consultants of Houston, Bellaire, Texas