Genetic Decryption of Leber Congenital Amaurosis (LCA) in a Large Cohort of Independent Families.

The main objectives of this study are:

1. Improve genetic counseling by establishment of prevalences of each of genetic subtypes within a expanded population of patients with LCA taking into account ethnicity of families.
2. Confirm, refine or modify the genotype-phenotype correlations.

3. Edit important recommendations for:

4. The clinical and paraclinical exploration of a new patient based on genotype, especially for extraocular explorations, to book at certain genetic subtypes

5. Prenatal care of a couple.
6. Directing families to a therapeutic protocol in progress or in development.
7. Individualize a panel of families without a mutation in the known genes and identify new genes responsible.