Trials / NCT02244996
Cone Rescue in Retinitis Pigmentosa by the Treatment of Lycium Barbarum
Completed N/A Other
- Sponsor
- The Hong Kong Polytechnic University
- Treatment
- Lycium Barbarum; Placebo
- Gene
- Not stated
- Conditions
- Retinitis Pigmentosa
- Ages
- 18 Years to 70 Years
- Enrollment
- 50 participants
- Started
- 2014-11
- Main results expected
- 2016-04
- Results posted
- Yes
- Record last updated
- 2019-02-19
What the study is testing
Objectives: To study the immediate effect and the persistent effect of Lycium barbarum (LB) treatment on retinal functions, especially the cone function, and retinal structure in patients with retinitis pigmentosa (RP) Design: Randomised controlled double-masked trial
Setting: Primary Care clinical trial
Participants: 120 RP subjects will be recruited from Ophthalmology department at The University of Hong Kong and the Retina Hong Kong. Interventions: Subjects will be randomly allocated to LB (treated with LB granules) or control (treated with placebo) groups for 1 year. After the 1st year, both groups will stop the treatment and all subjects will also have the same eye exam in 6-month period for the 2nd year.
Main outcome measures: The primary outcome is the total sensitivity scores of 30-2 \& 60-4 programmes of Humphrey Visual Field Analysis (HVFA). The secondary outcomes are the b-wave amplitudes of Full-field Electroretinogram (ffERG) responses, the amplitudes of direct component and induced component of Multifocal Electroretinogram (mfERG), and the ETDRS visual acuity.
Where it runs
Hong Kong (1)
- The Hong Kong Polytechnic University, Hong Kong