/* Designed for readers with retinitis pigmentosa:
   - one narrow central column (peripheral vision is what RP takes first)
   - navy/amber, the high-contrast pairing low-vision guidance recommends
   - Atkinson Hyperlegible, drawn by the Braille Institute for low-vision readers
   - user-adjustable text size and a real dark mode for glare sensitivity */

:root {
  --bg: #ffffff;
  --ink: #0e1a33;
  --muted: #34445f;
  --link: #1c47c9;
  --amber: #ffc83d;
  --on-amber: #0e1a33;
  --rule: #c3cde0;
  --panel: #eef2f9;
  --focus: #1c47c9;
  --measure: 38rem;
  font-size: 20px;
  color-scheme: light;
}
:root[data-size="s"]  { font-size: 18px; }
:root[data-size="l"]  { font-size: 24px; }
:root[data-size="xl"] { font-size: 28px; }

@media (prefers-color-scheme: dark) {
  :root:not([data-theme="light"]) {
    --bg: #0e1a33; --ink: #f6f3e8; --muted: #c9d0dd; --link: #ffc83d;
    --rule: #2f3f62; --panel: #16264a; --focus: #ffc83d; color-scheme: dark;
  }
}
:root[data-theme="dark"] {
  --bg: #0e1a33; --ink: #f6f3e8; --muted: #c9d0dd; --link: #ffc83d;
  --rule: #2f3f62; --panel: #16264a; --focus: #ffc83d; color-scheme: dark;
}

* { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; }
body {
  margin: 0;
  background: var(--bg);
  color: var(--ink);
  font-family: "Atkinson Hyperlegible Next", "Atkinson Hyperlegible", Verdana, sans-serif;
  font-size: 1rem;
  line-height: 1.55;
}
.wrap { max-width: var(--measure); margin: 0 auto; padding: 0 1.1rem; }

a { color: var(--link); text-underline-offset: 0.18em; text-decoration-thickness: 0.08em; }
a:hover { text-decoration-thickness: 0.16em; }
:focus-visible { outline: 0.2rem solid var(--focus); outline-offset: 0.15rem; border-radius: 2px; }

.skip { position: absolute; left: -999px; top: 0; background: var(--amber); color: var(--on-amber); padding: 0.6rem 1rem; z-index: 10; }
.skip:focus { left: 0.5rem; top: 0.5rem; }

/* ---------- header ---------- */
.masthead { border-bottom: 2px solid var(--ink); padding: 1rem 0 0.75rem; margin-bottom: 2rem; }
.brand { font-weight: 800; font-size: 1.15rem; color: var(--ink); text-decoration: none; display: inline-block; margin-bottom: 0.5rem; }
nav { display: flex; flex-wrap: wrap; gap: 0.25rem 1.1rem; margin-bottom: 0.6rem; }
nav a { color: var(--ink); font-weight: 600; text-decoration: none; padding: 0.15rem 0; border-bottom: 0.15rem solid transparent; }
nav a:hover { border-bottom-color: var(--rule); }
nav a[aria-current="page"] { border-bottom-color: var(--amber); }
.view-controls { display: flex; gap: 0.4rem; flex-wrap: wrap; }
.view-controls button {
  font: inherit; font-size: 0.8rem; font-weight: 600; color: var(--ink); background: transparent;
  border: 1.5px solid var(--rule); border-radius: 0.3rem; padding: 0.2rem 0.6rem; min-height: 2rem; cursor: pointer;
}
.view-controls button:hover { border-color: var(--ink); }

/* ---------- type ---------- */
h1, h2, h3 { line-height: 1.2; margin: 0; }
h1 { font-size: 2rem; font-weight: 800; letter-spacing: -0.01em; margin-bottom: 0.75rem; }
h2 { font-size: 1.35rem; font-weight: 800; margin: 2.5rem 0 0.75rem; }
h3 { font-size: 1.05rem; font-weight: 600; }
p { margin: 0 0 1rem; }
.lede { font-size: 1.1rem; color: var(--muted); }
.small { font-size: 0.85rem; color: var(--muted); }
.dateline { color: var(--muted); font-weight: 600; margin-bottom: 0.5rem; }
code { font-size: 0.9em; background: var(--panel); padding: 0.05em 0.3em; border-radius: 0.2em; }

/* the one loud thing: the week's news, highlighted like a marker on paper */
.hero { margin-bottom: 2.5rem; }
.hero h1 {
  font-size: clamp(2rem, 6vw, 2.8rem);
  line-height: 1.22;
  letter-spacing: -0.015em;
}
.hero h1 {
  background: linear-gradient(transparent 8%, var(--amber) 8%, var(--amber) 94%, transparent 94%);
  color: var(--on-amber);
  -webkit-box-decoration-break: clone; box-decoration-break: clone;
  padding: 0 0.2em;
  display: inline;
}
.hero h1 + .lede { margin-top: 1.25rem; }

/* ---------- sections ---------- */
.digest, .note { background: var(--panel); border-left: 0.35rem solid var(--amber); padding: 1rem 1.2rem 0.4rem; margin: 2rem 0; }
.digest h2, .note h2 { margin-top: 0; }

.list { list-style: none; padding: 0; margin: 0; }
.list > li { padding: 1rem 0; border-top: 1px solid var(--rule); }
.list > li:last-child { border-bottom: 1px solid var(--rule); }
.trial h3 a, .paper h3 a { color: var(--ink); }
.trial h3 a:hover, .paper h3 a:hover { color: var(--link); }
.facts { display: flex; flex-wrap: wrap; gap: 0.3rem 0.9rem; margin: 0.45rem 0 0.3rem; font-weight: 600; font-size: 0.9rem; }
.facts.big { font-size: 1rem; margin-bottom: 1.25rem; }
.who { color: var(--muted); font-size: 0.9rem; margin: 0; }
.change { font-weight: 600; margin: 0.4rem 0; }
.kind { font-weight: 700; color: var(--ink); margin-right: 0.3rem; }

.status { display: inline-block; padding: 0 0.45em; border-radius: 0.25em; border: 1.5px solid var(--rule); }
.s-recruiting, .s-not_yet_recruiting, .s-available { background: var(--amber); color: var(--on-amber); border-color: var(--amber); }
.s-terminated, .s-withdrawn, .s-suspended { border-style: dashed; border-color: var(--muted); }

details > summary { cursor: pointer; font-weight: 600; padding: 0.4rem 0; }
details > summary h2 { display: inline; }
.archive ul { list-style: none; padding: 0; display: flex; flex-wrap: wrap; gap: 0.4rem 1rem; }

/* ---------- forms ---------- */
.filters { display: grid; gap: 0.8rem; margin-bottom: 1.25rem; }
.filters.inline { display: block; }
label { display: grid; gap: 0.25rem; font-weight: 600; font-size: 0.9rem; }
input, select, textarea {
  font: inherit; font-size: 1rem; color: var(--ink); background: var(--bg);
  border: 2px solid var(--rule); border-radius: 0.3rem; padding: 0.45rem 0.6rem; min-height: 2.6rem; width: 100%;
}
input:focus, select:focus, textarea:focus { border-color: var(--focus); }
button, .button {
  font: inherit; font-weight: 700; background: var(--ink); color: var(--bg); border: 0; border-radius: 0.3rem;
  padding: 0.6rem 1.1rem; min-height: 2.6rem; cursor: pointer; text-decoration: none; display: inline-block;
}
button.quiet { background: transparent; color: var(--link); padding: 0 0.3rem; min-height: 0; font-weight: 600; text-decoration: underline; }
.stack { display: grid; gap: 0.8rem; }
.inline-form { display: inline; }
.count { font-weight: 600; color: var(--muted); }
.cta { margin-top: 2rem; }

/* ---------- trial page ---------- */
.trial-h { font-size: 1.6rem; }
.kv { display: grid; grid-template-columns: minmax(7rem, 38%) 1fr; gap: 0.5rem 1rem; margin: 0; }
.kv dt { font-weight: 700; }
.kv dd { margin: 0; }
.plain { list-style: none; padding: 0; margin: 0.3rem 0 0.8rem; }
.plain li { padding: 0.25rem 0; }
.summary { max-width: 100%; overflow-wrap: anywhere; }

/* ---------- pipeline ---------- */
.pipe { border-top: 2px solid var(--ink); margin-top: 2rem; }
.pipe h2 { margin-top: 0.8rem; }
.pipe-row { margin: 0.6rem 0 0.9rem 0; padding-left: 0.9rem; border-left: 0.2rem solid var(--rule); }
.pipe-row h3 { font-size: 0.95rem; color: var(--muted); }
.n { display: inline-block; min-width: 1.6em; text-align: center; background: var(--ink); color: var(--bg); border-radius: 0.8em; font-size: 0.8rem; padding: 0 0.35em; margin-left: 0.3em; }
.bars { list-style: none; padding: 0; margin: 0; }
.bars li { display: grid; grid-template-columns: 9rem 1fr 2.5rem; align-items: center; gap: 0.6rem; padding: 0.2rem 0; }
.bar { height: 0.85rem; width: var(--w); background: var(--ink); border-radius: 0 0.2rem 0.2rem 0; }
.bar-label { overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
.bar-n { font-weight: 700; text-align: right; }

.prose h2 { font-size: 1.2rem; }

.foot { border-top: 1px solid var(--rule); margin-top: 3.5rem; padding-top: 1rem; padding-bottom: 2.5rem; color: var(--muted); font-size: 0.85rem; }

@media (min-width: 46rem) {
  .filters { grid-template-columns: 1fr 1fr; }
  .filters label:first-child { grid-column: 1 / -1; }
  .filters button { justify-self: start; }
}
@media (prefers-reduced-motion: reduce) { * { transition: none !important; animation: none !important; } }
@media print { .masthead nav, .view-controls, .filters { display: none; } }
[hidden] { display: none !important; }